MDR GENES
\ˌɛmdˌiːˈɑː d͡ʒˈiːnz], \ˌɛmdˌiːˈɑː dʒˈiːnz], \ˌɛ_m_d_ˌiː__ˈɑː dʒ_ˈiː_n_z]\
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Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene familes. The human multidrug resistance 1; (MDR1); gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199 (3):1428-35; Cancer Res 1994:54 (6):1536-41)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.