MALIGNANT BRAIN NEOPLASM
\məlˈɪɡnənt bɹˈe͡ɪn nˈiːə͡ʊplˌazəm], \məlˈɪɡnənt bɹˈeɪn nˈiːəʊplˌazəm], \m_ə_l_ˈɪ_ɡ_n_ə_n_t b_ɹ_ˈeɪ_n n_ˈiː__əʊ_p_l_ˌa_z_ə_m]\
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Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.