M5041T
\ˈɛm fˈa͡ɪv θˈa͡ʊzənd ən fˈɔːtiwˈɒn tˈiː], \ˈɛm fˈaɪv θˈaʊzənd ən fˈɔːtiwˈɒn tˈiː], \ˈɛ_m f_ˈaɪ_v θ_ˈaʊ_z_ə_n_d ə_n f_ˈɔː_t_i_w_ˈɒ_n t_ˈiː]\
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An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.