LYMPHOCYTE ACTIVATIONS
\lˈɪmfəsˌa͡ɪt ˌaktɪvˈe͡ɪʃənz], \lˈɪmfəsˌaɪt ˌaktɪvˈeɪʃənz], \l_ˈɪ_m_f_ə_s_ˌaɪ_t ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n_z]\
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Morphologic alteration of small lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by interleukins, mitogens such as phytohemagglutinins, and by specific antigens. It may also occur in vivo, as in graft rejection and chronic myelogenous leukemia.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.