LYMPHANGIOSARCOMA
\lˌɪmfɐŋɡɪˌɒsɑːkˈə͡ʊmə], \lˌɪmfɐŋɡɪˌɒsɑːkˈəʊmə], \l_ˌɪ_m_f_ɐ_ŋ_ɡ_ɪ__ˌɒ_s_ɑː_k_ˈəʊ_m_ə]\
Definitions of LYMPHANGIOSARCOMA
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A malignant tumor originating from the endothelial cells of lymphatic vessels. Most lymphangiosarcomas arise in an arm secondary to radical mastectomy but they sometimes complicate idiopathic lymphedema. The lymphedema has usually been present for 6 to 10 years before malignant changes develop. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.