LOCKED IN SYNDROME
\lˈɒkt ɪn sˈɪndɹə͡ʊm], \lˈɒkt ɪn sˈɪndɹəʊm], \l_ˈɒ_k_t ɪ_n s_ˈɪ_n_d_ɹ_əʊ_m]\
Definitions of LOCKED IN SYNDROME
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Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
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