LOCALIZED SCLERODERMA
\lˈə͡ʊkə͡lˌa͡ɪzd sklˈɛɹə͡ʊdəmə], \lˈəʊkəlˌaɪzd sklˈɛɹəʊdəmə], \l_ˈəʊ_k_əl_ˌaɪ_z_d s_k_l_ˈɛ_ɹ_əʊ_d_ə_m_ə]\
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A chronic, localized hardening and thickening of the skin. Lesions may be categorized as morphea (guttate, profunda, pansclerotic) or linear (with or without melorheostosis or hemiatrophy). It is twice as common in women as in men. The condition is characterized by skin ischemia, lymphocytic infiltrates, swollen collagen bundles, and thickening of the dermis with reduction of subcutaneous fat.
By DataStellar Co., Ltd
