LOBAR ATROPHY (BRAIN)
\lˈə͡ʊbɑːɹ ˈatɹəfi bɹˈe͡ɪn], \lˈəʊbɑːɹ ˈatɹəfi bɹˈeɪn], \l_ˈəʊ_b_ɑː_ɹ ˈa_t_ɹ_ə_f_i__ b_ɹ_ˈeɪ_n]\
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A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8 (2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.