LIVEDO RETICULARIS, SYSTEMIC INVOLVEMENT
\lˈa͡ɪvdə͡ʊ ɹɛtˈɪkjʊlˌɑːɹɪs], \lˈaɪvdəʊ ɹɛtˈɪkjʊlˌɑːɹɪs], \l_ˈaɪ_v_d_əʊ ɹ_ɛ_t_ˈɪ_k_j_ʊ_l_ˌɑː_ɹ_ɪ_s]\
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A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of livedo reticularis, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54 (1):53-60)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
- liveborn
- liveborn infant
- lived
- livedo
- livedo reticularis
- Livedo Reticularis, Systemic Involvement
- liveli-hood
- livelihed
- livelihood
- livelily
- liveliness