LESLIE STEPHEN
\lˈɛsli stˈiːvən], \lˈɛsli stˈiːvən], \l_ˈɛ_s_l_i s_t_ˈiː_v_ə_n]\
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A distinguished English critic and man of letters; born in London, Nov. 28, 1832. He was educated at Cambridge, and subsequently edited leading London periodicals. His greatest undertaking was the "Dictionary of National Biography", in about 60 volumes, of which he edited the first 26. The work is still in course of publication. He has published: "Hours in a Library" (1871-79); "Essays on Free Thinking and Plain Speaking" (1873); "History of English Thought in the Eighteenth Century" (1876); "Science of Ethics" (1882); "Life of Henry Fawcett" (1885); "An Agnostic's Apology" (1893); "Life of Sir James Fitzjames Stephen" (1896); "Social Rights and Duties" (1896); etc. Died at London, Feb. 22, 1904.
By Charles Dudley Warner
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.