L TYPE VDCC
\ˈɛl tˈa͡ɪp vˌiːdˌiːsˌiːsˈiː], \ˈɛl tˈaɪp vˌiːdˌiːsˌiːsˈiː], \ˈɛ_l t_ˈaɪ_p v_ˌiː_d_ˌiː_s_ˌiː_s_ˈiː]\
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Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
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Word of the day
Quinones
- Hydrocarbon rings which contain two moieties position. They can be substituted in any position except at the ketone groups.
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