KIRSTEN MURINE SARCOMA VIRUS
\kˈɜːstən mjˈʊɹiːn sɑːkˈə͡ʊmə vˈa͡ɪɹəs], \kˈɜːstən mjˈʊɹiːn sɑːkˈəʊmə vˈaɪɹəs], \k_ˈɜː_s_t_ə_n m_j_ˈʊ_ɹ_iː_n s_ɑː_k_ˈəʊ_m_ə v_ˈaɪ_ɹ_ə_s]\
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A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) capable of transforming mouse lymphoid cells and producing erythroid leukemia after superinfection with murine leukemia viruses (LEUKEMIA VIRUS, MURINE). It has also been found to transform cultured human fibroblasts, rat liver epithelial cells, and rat adrenocortical cells.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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- Kirsten murine sarcoma virus
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