ISOASPARTIC ACID
\ˌa͡ɪsə͡ʊspˈɑːtɪk ˈasɪd], \ˌaɪsəʊspˈɑːtɪk ˈasɪd], \ˌaɪ_s_əʊ_s_p_ˈɑː_t_ɪ_k ˈa_s_ɪ_d]\
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An ASPARTIC ACID residue in polypeptide chains that is linked at the beta-carboxyl group instead of at the normal, alpha-carboxyl group, polypeptide linkage. It is a result of the spontaneous decomposition of aspartic acid or ASPARAGINE residues.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.