INVESTIGATIONAL THERAPIES
\ɪnvˌɛstɪɡˈe͡ɪʃənə͡l θˈɛɹəpɪz], \ɪnvˌɛstɪɡˈeɪʃənəl θˈɛɹəpɪz], \ɪ_n_v_ˌɛ_s_t_ɪ_ɡ_ˈeɪ_ʃ_ə_n_əl θ_ˈɛ_ɹ_ə_p_ɪ_z]\
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Pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.