INTERSTELIAR

\ˌɪntəstˈɛli͡ə], \ˌɪntəstˈɛli‍ə], \ˌɪ_n_t_ə_s_t_ˈɛ_l_iə]\
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1919 - The Concise Standard Dictionary of the English Language
By James Champlin Fernald

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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