INTEGRIN ALPHALBETA2
\ɪntˈɛɡɹɪn ˈalfəɹ ˈɛlbˌiːtə tˈuː], \ɪntˈɛɡɹɪn ˈalfəɹ ˈɛlbˌiːtə tˈuː], \ɪ_n_t_ˈɛ_ɡ_ɹ_ɪ_n ˈa_l_f_ə_ɹ ˈɛ_l_b_ˌiː_t_ə t_ˈuː]\
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A heterodimer molecule widely expressed on cells of hematopoietic origin. CD11a antigen comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. LFA-1 is a major receptor of T-cells, B-cells, and granulocytes. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Intracellular adhesion molecule-1 (ICAM-1) has been defined as a ligand for LFA-1.
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