INSERTION SEQUENCE ELEMENT
\ɪnsˈɜːʃən sˈiːkwəns ˈɛlɪmənt], \ɪnsˈɜːʃən sˈiːkwəns ˈɛlɪmənt], \ɪ_n_s_ˈɜː_ʃ_ə_n s_ˈiː_k_w_ə_n_s ˈɛ_l_ɪ_m_ə_n_t]\
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Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.