\ɪnɐdˈaptəbə͡l], \ɪnɐdˈaptəbə‍l], \ɪ_n_ɐ_d_ˈa_p_t_ə_b_əl]\
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  • in-a-dap'ta-bl, adj. that cannot be adapted.--n. INADAPT[=A]'TION.--adj. INADAP'TIVE.
1908 - Chambers's Twentieth Century Dictionary of the English Language
By Thomas Davidson

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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