IMMUNOGLOBULIN CLASS SWITCHING
\ɪmjˈuːnəɡlˌɒbjʊlˌɪn klˈas swˈɪt͡ʃɪŋ], \ɪmjˈuːnəɡlˌɒbjʊlˌɪn klˈas swˈɪtʃɪŋ], \ɪ_m_j_ˈuː_n_ə_ɡ_l_ˌɒ_b_j_ʊ_l_ˌɪ_n k_l_ˈa_s s_w_ˈɪ_tʃ_ɪ_ŋ]\
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Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
By DataStellar Co., Ltd
