IMMUNOCONJUGATE
\ɪmjˈuːnəkˌɒnd͡ʒuːɡˌe͡ɪt], \ɪmjˈuːnəkˌɒndʒuːɡˌeɪt], \ɪ_m_j_ˈuː_n_ə_k_ˌɒ_n_dʒ_uː_ɡ_ˌeɪ_t]\
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Combinations of diagnostic or therapeutic substances linked with specific immune substances such as immunoglobulins, monoclonal antibodies or antigens. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of drugs and radioisotopes in the chemotherapy and radioimmunotherapy of certain cancers.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.