IG SWITCH SEQUENCE
\ˈɪɡ swˈɪt͡ʃ sˈiːkwəns], \ˈɪɡ swˈɪtʃ sˈiːkwəns], \ˈɪ_ɡ s_w_ˈɪ_tʃ s_ˈiː_k_w_ə_n_s]\
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A site on a segment of a B-cell immunoglobulin heavy-chain gene where recombination (or rearrangement) can occur. It is involved in isotype or allotype switching and maturation of the immune response. Ig switch regions are found on genes encoding all five immunoglobulin heavy chains.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.