IG CONSTANT REGION
\ˈɪɡ kˈɒnstənt ɹˈiːd͡ʒən], \ˈɪɡ kˈɒnstənt ɹˈiːdʒən], \ˈɪ_ɡ k_ˈɒ_n_s_t_ə_n_t ɹ_ˈiː_dʒ_ə_n]\
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That region of the immunoglobulin (antibody) molecule that is invariable in its amino acid sequence within any class of immunoglobulins. It confers the biological specificity to the Ig and is grossly species specific. It comprises the C-terminus half of the light chains and three quarters or more of the heavy chains, all of the Fc fragment, and the C-terminus half of the Fab fragment.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.