Definitions of Ia Like Antigens, Human

  1. Human immune- response or Class II antigens found mainly, but not exclusively, on B- lymphocytes and produced from genes of the HLA- D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the - DR, - DQ and - DP designations, of which HLA- DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.