HYPOXIC ISCHEMIC ENCEPHALOPATHIES
\hˌa͡ɪpə͡ʊzˈɪk ɪskˈiːmɪk ɛnsˌɛfɐlˈɒpəθɪz], \hˌaɪpəʊzˈɪk ɪskˈiːmɪk ɛnsˌɛfɐlˈɒpəθɪz], \h_ˌaɪ_p_əʊ_z_ˈɪ_k ɪ_s_k_ˈiː_m_ɪ_k ɛ_n_s_ˌɛ_f_ɐ_l_ˈɒ_p_ə_θ_ɪ_z]\
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A disorder characterized by a reduction in oxygen supply (HYPOXIA) combined with reduced blood flow (ISCHEMIA) to the brain. This condition may result from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.