HIV 1 LTR
\ˌe͡ɪt͡ʃˌa͡ɪvˈiː wˈɒn ˌɛltˌiːˈɑː], \ˌeɪtʃˌaɪvˈiː wˈɒn ˌɛltˌiːˈɑː], \ˌeɪ_tʃ_ˌaɪ_v_ˈiː w_ˈɒ_n ˌɛ_l_t_ˌiː__ˈɑː]\
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Regulatory sequences important for viral replication that are located on each end of the HIV genome. The LTR includes the HIV ENHANCER, promoter, and other sequences. Specific regions in the LTR include the negative regulatory element (NRE), NF-kappa B binding sites , Sp1 binding sites, TATA BOX, and trans-acting responsive element (TAR). The binding of both cellular and viral proteins to these regions regulates HIV transcription.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.