HGF RECEPTOR
\ˌe͡ɪt͡ʃd͡ʒˌiːˈɛf ɹɪsˈɛptə], \ˌeɪtʃdʒˌiːˈɛf ɹɪsˈɛptə], \ˌeɪ_tʃ_dʒ_ˌiː__ˈɛ_f ɹ_ɪ_s_ˈɛ_p_t_ə]\
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A cell surface protein-tyrosine kinase receptor for HEPATOCYTE GROWTH FACTOR. It consists of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and critical sites for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEIN C-MET are associated with papillary renal carcinoma and other neoplasia. EC 2.7.11.-.
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