HEME CONTROLLED INHIBITOR
\hˈiːm kəntɹˈə͡ʊld ɪnhˈɪbɪtə], \hˈiːm kəntɹˈəʊld ɪnhˈɪbɪtə], \h_ˈiː_m k_ə_n_t_ɹ_ˈəʊ_l_d ɪ_n_h_ˈɪ_b_ɪ_t_ə]\
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A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, eiF-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of eIF-2, leading to the inhibition of protein synthesis. EC 2.7.10.-
By DataStellar Co., Ltd
