HEAVY CHAIN DISEASE
\hˈɛvi t͡ʃˈe͡ɪn dɪzˈiːz], \hˈɛvi tʃˈeɪn dɪzˈiːz], \h_ˈɛ_v_i tʃ_ˈeɪ_n d_ɪ_z_ˈiː_z]\
Definitions of HEAVY CHAIN DISEASE
Sort: Oldest first
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
By DataStellar Co., Ltd
Word of the day
- Treatment diffuse suppurative peritonitis elevation head bed so as to favor drainage tube passed through an incision in the right iliac fossa, and by continuous irrigation of rectum with a physiological salt solution.