HB420
\ˌe͡ɪt͡ʃbˈiː fˈɔːhˈʌndɹədən twˈɛnti], \ˌeɪtʃbˈiː fˈɔːhˈʌndɹədən twˈɛnti], \ˌeɪ_tʃ_b_ˈiː f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n t_w_ˈɛ_n_t_i]\
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.