H1 RECEPTORS
\ˈe͡ɪt͡ʃ wˈɒn ɹɪsˈɛptəz], \ˈeɪtʃ wˈɒn ɹɪsˈɛptəz], \ˈeɪ_tʃ w_ˈɒ_n ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20 (1):122-5)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.