GTP 8 FORMYLHYDROLASE
\d͡ʒˌiːtˌiːpˈiː ˈe͡ɪt fˈɔːmɪlhˌa͡ɪdɹəlˌe͡ɪs], \dʒˌiːtˌiːpˈiː ˈeɪt fˈɔːmɪlhˌaɪdɹəlˌeɪs], \dʒ_ˌiː_t_ˌiː_p_ˈiː_ ˈeɪ_t f_ˈɔː_m_ɪ_l_h_ˌaɪ_d_ɹ_ə_l_ˌeɪ_s]\
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(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
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