\d͡ʒˈɛnəs ɐplˈɪzi͡ə], \d‍ʒˈɛnəs ɐplˈɪzi‍ə], \dʒ_ˈɛ_n_ə_s ɐ_p_l_ˈɪ_z_iə]\
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2011 - English Dictionary Database
By DataStellar Co., Ltd
2006 - WordNet 3.0
By Princeton University

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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