GENERAL AGENCY SYSTEM

\d͡ʒˈɛnəɹə͡l ˈe͡ɪd͡ʒənsi sˈɪstəm], \d‍ʒˈɛnəɹə‍l ˈe‍ɪd‍ʒənsi sˈɪstəm], \dʒ_ˈɛ_n_ə_ɹ_əl ˈeɪ_dʒ_ə_n_s_i s_ˈɪ_s_t_ə_m]\

Definitions of GENERAL AGENCY SYSTEM

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1910 - Black's Law Dictionary (2nd edition)
By Henry Campbell Black

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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