G PROTEIN REGULATING FACTORS
\d͡ʒˈiː pɹˈə͡ʊtiːn ɹˈɛɡjuːlˌe͡ɪtɪŋ fˈaktəz], \dʒˈiː pɹˈəʊtiːn ɹˈɛɡjuːlˌeɪtɪŋ fˈaktəz], \dʒ_ˈiː p_ɹ_ˈəʊ_t_iː_n ɹ_ˈɛ_ɡ_j_uː_l_ˌeɪ_t_ɪ_ŋ f_ˈa_k_t_ə_z]\
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Proteins that regulate the signaling activity of GTP-BINDING PROTEINS. They are divided into three categories depending upon whether they stimulate GTPase activity (GTPASE-ACTIVATING PROTEINS), inhibit release of GDP; (GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS); or exchange GTP for GDP; (GUANINE NUCLEOTIDE EXCHANGE FACTORS).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.