FRAMESHIFT MUTATION
\fɹˈe͡ɪmʃɪft mjuːtˈe͡ɪʃən], \fɹˈeɪmʃɪft mjuːtˈeɪʃən], \f_ɹ_ˈeɪ_m_ʃ_ɪ_f_t m_j_uː_t_ˈeɪ_ʃ_ə_n]\
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A type of mutation in which a number of nucleotides not divisible by three is deleted from or inserted into a coding sequence, thereby causing an alteration in the reading frame of the entire sequence downstream of the mutation. These mutations may be induced by certain types of mutagens or may occur spontaneously.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.