FOREFINGER
\fˈɔːfɪŋɡə], \fˈɔːfɪŋɡə], \f_ˈɔː_f_ɪ_ŋ_ɡ_ə]\
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By William Hand Browne, Samuel Stehman Haldeman
By Stormonth, James, Phelp, P. H.
Word of the day
ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.