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\fˈe͡ɪsɪŋ pˈe͡ɪd͡ʒɪz], \fˈe‍ɪsɪŋ pˈe‍ɪd‍ʒɪz], \f_ˈeɪ_s_ɪ_ŋ p_ˈeɪ_dʒ_ɪ_z]\
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2006 - WordNet 3.0
By Princeton University
 
2011 - English Dictionary Database
By DataStellar Co., Ltd

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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