FACILITY TAKEOVER

\fəsˈɪlɪti tˈe͡ɪkə͡ʊvə], \fəsˈɪlɪti tˈe‍ɪkə‍ʊvə], \f_ə_s_ˈɪ_l_ɪ_t_i t_ˈeɪ_k_əʊ_v_ə]\

Definitions of FACILITY TAKEOVER

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1910 - Black's Law Dictionary (2nd edition)
By Henry Campbell Black

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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