action that makes a problem or a disease ( or its symptoms) worse; " the aggravation of her condition resulted from lack of care"

violent and bitter exasperation; " his foolishness was followed by an exacerbation of their quarrel"

The act rendering more violent or bitter; the state of being exacerbated or intensified in violence or malignity; as, exacerbation of passion.

A periodical increase of violence in a disease, as in remittent or continious fever; an increased energy of diseased and painful action.

An increase in the severity of a disease or any of its symptoms.

The act of exascerbating; increase of malignity; s periodical increase of violence in the course of a disease; increased severity.

The act of irritating highly; increase of violence in a disease.

He very justly says: " The narrower the sphere of activity in which these individuals live, the more frequent the opportunities for conflict are offered by law, discipline, and subordination, the easier it is to develop a psychotic exacerbation of the abnormal temperament even on a lesser pathological basis. – Studies in Forensic Psychiatry by Bernard Glueck

In each of these Cases Vinegar, used externally and internally, is the best Remedy during the Exacerbation or Height of the Paroxysm; and Plenty of Lemon Juice and Water after it. – Advice to the people in general, with regard to their health by Samuel Auguste David Tissot

I know too well from experience the progress of political controversy, and the exacerbation of spirit into which it degenerates, not to fear for the continuance of your mutual esteem. – Memoir, Correspondence, And Miscellanies, From The Papers Of Thomas Jefferson by Thomas Jefferson

But the spring was always her worst time as to health; and during this customary vernal exacerbation of illness, in April, 1866, she found herself obliged at last, after fourteen years' service, to send in her resignation to the Daily News. – Harriet Martineau by Florence Fenwick Miller

During the examination of Ready- Money Jack, Slingsby had stood like " dejected Pity at his side," seeking every now and then, by a soft word, to soothe any exacerbation of his ire, or to qualify any harsh expression. – Bracebridge Hall, or The Humorists by Washington Irving

But exacerbation tells, even in the young, and at Piccadilly Circus, Lucas, in obeying a too suddenly uplifted hand of a policeman, stopped his engine. – The Roll-Call by Arnold Bennett

That they had failed of their mission was something that fretted Victor Vassilyevski, his mind and nerves, to a pitch of exacerbation all but unendurable. – Red Masquerade by Louis Joseph Vance

He remarked a steadily intensified exacerbation of nerves, and told himself he was growing old and no mistake. – Alias The Lone Wolf by Louis Joseph Vance

After a debate of excessive exacerbation, lasting for four days, only twenty votes could be found indirectly and remotely to censure. – Memoir of the Life of John Quincy Adams. by Josiah Quincy

They had begun to comprehend this exacerbation of emotion- this paroxysmal rhapsody. – A Protegee of Jack Hamlin's and Other Stories by Bret Harte

The ache continued and at the end of about a year there was an acute exacerbation which justified an operation, and the stone was removed. – Psychotherapy by James J. Walsh

And with the compulsory indolence of your life, the long exacerbation of the nervous system, will come the first pain of nostalgia,- the first weariness of the tropics. – Two Years in the French West Indies by Lafcadio Hearn

With such exacerbation of temper at the commencement of negotiations, their progress was of necessity stormy and slow. – Project Gutenberg History of The Netherlands, 1555-1623, Complete by John Lothrop Motley

You may, indeed, find it tedious, for example, to picture in vivid detail all the worries that have brought about your wife's exacerbation- negligent maid, dishonest tradesman, milk in a thunder storm, hypercritical husband, dirt in the wrong place- but, when you have faithfully done so, I absolutely defy you to speak to her in the same tone as you used to employ, and to cherish resentment against her as you used to do. – The Feast of St. Friend by Arnold Bennett

It is this that predisposes the patient to the development of the condition which seems to be so acute and yet is really only an exacerbation of a chronic condition. – Psychotherapy by James J. Walsh

As I sauntered back to the hotel I was conscious of a slight feeling of exacerbation. – Amusement Only by Richard Marsh