EXACERBATIO

\ɛɡzˌasəbˈe͡ɪʃɪˌə͡ʊ], \ɛɡzˌasəbˈe‍ɪʃɪˌə‍ʊ], \ɛ_ɡ_z_ˌa_s_ə_b_ˈeɪ_ʃ_ɪ__ˌəʊ]\
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1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison