ETHACRINIC ACID
\ˌɛθɐkɹˈɪnɪk ˈasɪd], \ˌɛθɐkɹˈɪnɪk ˈasɪd], \ˌɛ_θ_ɐ_k_ɹ_ˈɪ_n_ɪ_k ˈa_s_ɪ_d]\
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A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracelluar fluid. This compound has been classified as a loop or high ceiling diuretic.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.