ENCEPHALTIS, INCLUSION BODY, MEASLES
\ɛnsˈɛfɐltˌiz], \ɛnsˈɛfɐltˌiz], \ɛ_n_s_ˈɛ_f_ɐ_l_t_ˌi_z]\
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A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
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Nearby Words
- encephalothlipsis
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- Encephaltis, Inclusion Body, Measles
- encephalum
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- enchafe
- enchafing
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