ENCEPHALOPATHY, SUBACUTE NECROTIZING, JUVENILE
\ɛnsˌɛfɐlˈɒpəθɪ], \ɛnsˌɛfɐlˈɒpəθɪ], \ɛ_n_s_ˌɛ_f_ɐ_l_ˈɒ_p_ə_θ_ɪ]\
Definitions of ENCEPHALOPATHY, SUBACUTE NECROTIZING, JUVENILE
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A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
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- encephalopathy, binswangers
- encephalopathy, metabolic, acquired
- encephalopathy, post traumatic, chronic
- encephalopathy, subacute necrotizing, infantile
- Encephalopathy, Subacute Necrotizing, Juvenile
- encephalopathy, subcortical, chronic progressive