\ˈɛməɹˌɪt͡ʃskˈɒlsəɹəm], \ˈɛməɹˌɪt‍ʃskˈɒlsəɹəm], \ˈɛ_m_ə_ɹ_ˌɪ_tʃ_s_k_ˈɒ_l_s_ə_ɹ_ə_m]\


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1920 - A practical medical dictionary.
By Stedman, Thomas Lathrop

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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