DYSTONIC RIGID CEREBRAL PALSIES
\dɪstˈɒnɪk ɹˈɪd͡ʒɪd səɹˈiːbɹə͡l pˈɔːlziz], \dɪstˈɒnɪk ɹˈɪdʒɪd səɹˈiːbɹəl pˈɔːlziz], \d_ɪ_s_t_ˈɒ_n_ɪ_k ɹ_ˈɪ_dʒ_ɪ_d s_ə_ɹ_ˈiː_b_ɹ_əl p_ˈɔː_l_z_i_z]\
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A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40 (8):520-7)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.