DYSKINETIC CEREBRAL PALSY
\dˌɪska͡ɪnˈɛtɪk səɹˈiːbɹə͡l pˈɔːlzi], \dˌɪskaɪnˈɛtɪk səɹˈiːbɹəl pˈɔːlzi], \d_ˌɪ_s_k_aɪ_n_ˈɛ_t_ɪ_k s_ə_ɹ_ˈiː_b_ɹ_əl p_ˈɔː_l_z_i]\
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A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40 (8):520-7)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.