DUCHENNE MUSCULAR DYSTROPHY
\dˈʌt͡ʃən mˈʌskjʊlə dˈɪstɹəfi], \dˈʌtʃən mˈʌskjʊlə dˈɪstɹəfi], \d_ˈʌ_tʃ_ə_n m_ˈʌ_s_k_j_ʊ_l_ə d_ˈɪ_s_t_ɹ_ə_f_i]\
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An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
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hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.