DNA TOPOISOMERASE (ATP HYDROLYSING)
\dˌiːˌɛnˈe͡ɪ tˈɒpɔ͡ɪsˌə͡ʊmɹe͡ɪz ˌe͡ɪtˌiːpˈiː hˈa͡ɪdɹəlˌa͡ɪzɪŋ], \dˌiːˌɛnˈeɪ tˈɒpɔɪsˌəʊmɹeɪz ˌeɪtˌiːpˈiː hˈaɪdɹəlˌaɪzɪŋ], \d_ˌiː__ˌɛ_n_ˈeɪ t_ˈɒ_p_ɔɪ_s_ˌəʊ_m_ɹ_eɪ_z__ ˌeɪ_t_ˌiː_p_ˈiː h_ˈaɪ_d_ɹ_ə_l_ˌaɪ_z_ɪ_ŋ]\
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DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
By DataStellar Co., Ltd
Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.