DISTAL SPINAL MUSCULAR ATROPHY

\dɪstˈal spˈa͡ɪnə͡l mˈʌskjʊləɹ ˈatɹəfi], \dɪstˈal spˈa‍ɪnə‍l mˈʌskjʊləɹ ˈatɹəfi], \d_ɪ_s_t_ˈa_l s_p_ˈaɪ_n_əl m_ˈʌ_s_k_j_ʊ_l_ə_ɹ ˈa_t_ɹ_ə_f_i]\

Definitions of DISTAL SPINAL MUSCULAR ATROPHY

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2010 - Medical Dictionary Database
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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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