DIFFUSE WELL DIFFERENTIATED LYMPHOCYTIC LYMPHOMA
\dɪfjˈuːz wˈɛl dˌɪfəɹˈɛnʃɪˌe͡ɪtɪd lˌɪmfəsˈɪtɪk lɪmfˈə͡ʊmə], \dɪfjˈuːz wˈɛl dˌɪfəɹˈɛnʃɪˌeɪtɪd lˌɪmfəsˈɪtɪk lɪmfˈəʊmə], \d_ɪ_f_j_ˈuː_z w_ˈɛ_l d_ˌɪ_f_ə_ɹ_ˈɛ_n_ʃ_ɪ__ˌeɪ_t_ɪ_d l_ˌɪ_m_f_ə_s_ˈɪ_t_ɪ_k l_ɪ_m_f_ˈəʊ_m_ə]\
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A low-grade malignant lymphoma that may, in some cases, be considered histologically identical to chronic lymphocytic leukemia (CLL; LEUKEMIA, LYMPHOCYTIC, CHRONIC). It is diffuse in pattern, representing the neoplastic proliferation of well-differentiated B-lymphocytes. In patients with immunoglobulin gammopathies, the lymphocytes may exhibit plasmacytoid characteristics.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.